A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain. Bohlen CJ, Priel A, Zhou S, King D, Siemens J*, Julius D*. Cell. 2010 May 28;141(5):834-45. *corresponding authors
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TRPA1 mediates formalin-induced pain. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30.
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Trevisani M*, Siemens J*, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. *denotes equal contribution
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The menthol receptor TRPM8 is the principal detector of environmental cold. Bautista DM*, Siemens J*, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. Nature. 2007 Jul 12;448(7150):204-8. Epub 2007 May 30. *denotes equal contribution
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Spider toxins activate the capsaicin receptor to produce inflammatory pain. Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. Nature. 2006 Nov 9;444(7116):208-12.
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Cadherin 23 is a component of the tip link in hair-cell stereocilia. Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U. Nature. 2004 Apr 29;428(6986):950-5.
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The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Müller U. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14946-51.
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