TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. Song K, Wang H, Kamm G, Pohle J, de Castro Reis F, Heppenstall P, Wende H, Siemens J. 2016, SCIENCE 23 Sep, Vol. 353, Issue 6306, pp. 1393-1398.
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TRP ion channels in thermosensation, thermoregulation and metabolism. Wang H, Siemens J. 2015, Temperature, 2:2, 178-187, DOI:10.1080/23328940.2015.1040604.
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GABA Blocks Pathological but Not Acute TRPV1 Pain Signals. Hanack C, Moroni M, Lima W, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich H, Gassmann M, Roggenkamp D, Bettler B, Lewin G, Selbach M, and Siemens J. 2015, Cell 160, 759-770.
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PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Schrenk-Siemens K, Wende H, Prato1 V, Song S, Rostock R, Loewer A, Utikal J, Lewin G, Lechner S & Siemens J. 2015, Nature Neuroscience 18, 759-770.
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A somatosensory circuit for cooling perception in mice. Milenkovic N, Zhao WJ, Walcher J, Albert T, Siemens J, Lewin GR, Poulet JF. 2014, Nature Neuroscience, 17 (11): 1560-66

Modulation of TRP Ion Channels by Venomous Toxins. Siemens J and Hanack C. 2014, Mammalian Transient Receptor Potential (TRP) Cation Channels – Handbook of Experimental Pharmacology, Vol.223, pp1119-1142.
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Proteolytic processing of the protein tyrosine phosphatase alpha extracellular domain is mediated by ADAM17/TACE. Kapp* K, Siemens* J, Häring H-U, Lammers R. 2012, Eur J Cell Biol, 91, 687-693. *denotes equal contribution
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Sensory transduction, the gateway to perception: mechanisms and pathology. Lechner S, Siemens J. 2011, Embo Reports, 12, 292-295.
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A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Bohlen C, Priel A, Zhou S, King D, Siemens* J and Julius* D. 2010, Cell, 141, 834-845. * Corresponding Authors
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TRPA1 mediates formalin-induced pain. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30.
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Trevisani M*, Siemens J*, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. *denotes equal contribution
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The menthol receptor TRPM8 is the principal detector of environmental cold. Bautista DM*, Siemens J*, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. Nature. 2007 Jul 12;448(7150):204-8. Epub 2007 May 30. *denotes equal contribution
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Spider toxins activate the capsaicin receptor to produce inflammatory pain. Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. Nature. 2006 Nov 9;444(7116):208-12.
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Cadherin 23 is a component of the tip link in hair-cell stereocilia. Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U. Nature. 2004 Apr 29;428(6986):950-5.
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The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Müller U. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14946-51.
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