GABA Blocks Pathological but Not Acute TRPV1 Pain Signals. Hanack C, Moroni M, Lima W, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich H, Gassmann M, Roggenkamp D, Bettler B, Lewin G, Selbach M, and Siemens J. 2015, Cell 160, 759-770.
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PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Schrenk-Siemens K, Wende H, Prato1 V, Song S, Rostock R, Loewer A, Utikal J, Lewin G, Lechner S & Siemens J. 2015, Nature Neuroscience 18, 759-770.
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Modulation of TRP Ion Channels by Venomous Toxins. Siemens J and Hanack C. 2014, Mammalian Transient Receptor Potential (TRP) Cation Channels – Handbook of Experimental Pharmacology, Vol.223, pp1119-1142.
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Proteolytic processing of the protein tyrosine phosphatase alpha extracellular domain is mediated by ADAM17/TACE. Kapp* K, Siemens* J, Häring H-U, Lammers R. 2012, Eur J Cell Biol, 91, 687-693. *denotes equal contribution
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Sensory transduction, the gateway to perception: mechanisms and pathology. Lechner S, Siemens J. 2011, Embo Reports, 12, 292-295.
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A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Bohlen C, Priel A, Zhou S, King D, Siemens* J and Julius* D. 2010, Cell, 141, 834-845. * Corresponding Authors
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TRPA1 mediates formalin-induced pain. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30.
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Trevisani M*, Siemens J*, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. *denotes equal contribution
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The menthol receptor TRPM8 is the principal detector of environmental cold. Bautista DM*, Siemens J*, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. Nature. 2007 Jul 12;448(7150):204-8. Epub 2007 May 30. *denotes equal contribution
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Spider toxins activate the capsaicin receptor to produce inflammatory pain. Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. Nature. 2006 Nov 9;444(7116):208-12.
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Cadherin 23 is a component of the tip link in hair-cell stereocilia. Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U. Nature. 2004 Apr 29;428(6986):950-5.
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The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Müller U. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14946-51.
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